Differential diagnosis of erectile dysfunction

 Erectile dysfunction means an inability for an adult male to sustained an adequate erection to allow penetration.

 

Organic causes Drug causes
  • Smoking - major
  • Alcohol – major
  • Diabetes mellitus (DM) – major
  • Endocrine causes : hypogonadism, hyperthyroidism, prolactin excess, androgen deficiency, primary gonadal failure
  • Neurological causes: spinal cord lesions, myasthenia gravis, autonomic neuropathy (e.g.: DM)
  • Radiotherapy
  • Renal failure
  • Hepatic failure
  • Prostatic hyperthrophy
  • Surgical causes : post bladder-neck prostate surgery, post prostatectomy
  • Penile abnormality : peyronie disease, post priapism
  • Venous leak (valve incompetence)
  • Vascular causes: peripheral vascular disease, aortoiliac occlusion, hypogastric-cavernous occlusion, pudendal artery occlusion
 

  • Antihypertensive – e.g.: beta blockers, diuretics, thiazide, methyldopa, clonidine
  • Digoxin
  • Major tranquilizers
  • Alcohol
  • Oestrogens
  • Levodopa
  • Opiates
  • Antidepressants – e.g.: monoamine oxidase (MOA) inhibitors, tricyclics
  • Barbiturates
  • Lithium
  • H2 blockers – e.g.: cimetidine
  • Steroids
  • Cancer chemotherapeutic
  • Metoclopramide
  • Phenytoin
  • Phenothiazine
  • Indomethacine
  • Antihistamine
  • Spirinolactone
  • Ketoconazole
  •  

    If everything has been ruled out, the possible cause is psychological. Most of the time, the cause of erectile dysfunction is multifactorial.

     

                   

     

     

    Reference:

    1. Murray Longmore et al. Oxford handbook of Clinical Medicine. 7th edition
    2. David S. Smith et al. Field Guide to Bedside diagnosis. 2nd edition. 2007. Lippincott Williams and Wilkins.
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    4 Responses to “Differential diagnosis of erectile dysfunction”

    1. john09 Says:

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    3. nick@howtodelayejaculation Says:

      Men need to listern to their bodies if they have ED. It could be that an underlying condition is causing the problem. Treat the causes and it may improve your whole life.

      Regards

      Nick

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