Conditions Associated with Clubbing-Health awareness

Conditions Associated with Clubbing

Clubbing is usually bilateral and painless. Acquired clubbing is often reversible in nature when the associated disease has been successfully treated.

Symmetrical Clubbing

Pulmonary disease
Neoplasm – Bronchogenic carcinoma, pleural mesothelioma, thymoma, metastatic carcinoma
Chronic infection – Lung abscess, chronic empyema, pneumoconiosis, chronic pneumonitis, cystic fibrosis, emphysema with chronic suppuration, actinomycosis, bronchiectasis

Cardiovascular disease
Cyanotic congenital heart disease
Subacute bacterial endocarditis
Cor pulmonale
Secondary polycythemia
Chronic congestive heart failure
Cardiac tumors
Pulmonary arteriovenous fistula
Arterial graft infection
Hepatic and gastrointestinal disease
Hepatic – Cirrhosis (all types), amebic abscess, amyloidosis
Gastrointestinal – Chronic infection (Ascariasis, malaria, intestinal tuberculosis, chronic amebic dysentery, chronic inflammation), ulcerative colitis (Regional enteritis, sprue) and neoplasm (Intestinal polyposis, abdominal lymphoma, nasopharyngeal carcinoma, esophageal carcinoma, gastric carcinoma, colonic carcinoma)

Miscellaneous
Endocrine conditions – Hyperthyroidism, hyperparathyroidism, pregnancy ( it may be recurrent during pregacy in otherwise healthy women)
Chronic infections – Chronic osteomyelitis with amyloidosis, chronic pyelonephritis
Congenital disorders – Muscular dystrophy, hemoglobinopathies
Idiopathic disorders – Chronic mountain sickness, syringomyelia
Neoplasms – Renal carcinoma, chronic myelocytic leukemia
Toxin exposure – Arsenic, mercury, silica, beryllium, phosphorus, alcohol, chronic laxative abuse
Familial – there is no clinical importance

Asymmetrical Clubbing

Unilateral – Anomalous aortic arch, aortic or subclavian artery aneurysm, pulmonary hypertension with patent ductus arteriosus, brachial arteriovenous aneurysm or fistula, recurrent shoulder dislocation, superior sulcus (Pancoast) tumor
Unidigital – Median nerve injury, sarcoidosis
Clubbing of toes without fingers – Coarctation of aorta

Reference:

http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=cm&part=A1328